Author: Imai-Matsushima, Aki; Martin-Sancho, Laura; Karlas, Alexander; Imai, Seiichiro; Zoranovic, Tamara; Hocke, Andreas C.; Mollenkopf, Hans-Joachim; Berger, Hilmar; Meyer, Thomas F.
Title: Long-Term Culture of Distal Airway Epithelial Cells Allows Differentiation Towards Alveolar Epithelial Cells Suited for Influenza Virus Studies Document date: 2018_6_22
ID: vopbw1tl_2
Snippet: The human alveolar epithelium is lined with non-proliferative type I alveolar epithelial (AEI) cells specialized for gas exchange, and proliferative type II alveolar epithelial (AEII) cells, which produce surfactant proteins with essential roles during innate immune responses [1, 2] . AEII cells are targeted by various pathogens that cause life-threatening pneumonia, several of which have a zoonotic origin [3] . This includes influenza A virus (I.....
Document: The human alveolar epithelium is lined with non-proliferative type I alveolar epithelial (AEI) cells specialized for gas exchange, and proliferative type II alveolar epithelial (AEII) cells, which produce surfactant proteins with essential roles during innate immune responses [1, 2] . AEII cells are targeted by various pathogens that cause life-threatening pneumonia, several of which have a zoonotic origin [3] . This includes influenza A virus (IAV), whose natural reservoir is birds but which has undergone human adaptation causing serious pandemics [4] [5] [6] [7] [8] [9] . Comparative studies using available cell types to study IAV zoonosis, such as human lung adenocarcinoma cell line A549 and the chicken embryonic fibroblast cell line DF-1, are likely to confound species-, tissue-, and cell line-specific effects. Therefore, establishing human and avian primary cell models would enable more physiologically relevant comparison.
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