Author: Imai-Matsushima, Aki; Martin-Sancho, Laura; Karlas, Alexander; Imai, Seiichiro; Zoranovic, Tamara; Hocke, Andreas C.; Mollenkopf, Hans-Joachim; Berger, Hilmar; Meyer, Thomas F.
Title: Long-Term Culture of Distal Airway Epithelial Cells Allows Differentiation Towards Alveolar Epithelial Cells Suited for Influenza Virus Studies Document date: 2018_6_22
ID: vopbw1tl_39
Snippet: By contrast, we found many genes upregulated during default differentiation that have been associated with idiopathic pulmonary fibrosis, e.g. CCL2 [40] , CCL3 [41] , SERPINE2 [42] , [43] and MMP7 [44, 45] . Current tools to support research in this field include animal models, cell lines such as the AEII cell line A549, non-epithelial models, as well as primary human bronchial epithelial, airway and alveolar epithelial cells [46] [47] [48] [49] .....
Document: By contrast, we found many genes upregulated during default differentiation that have been associated with idiopathic pulmonary fibrosis, e.g. CCL2 [40] , CCL3 [41] , SERPINE2 [42] , [43] and MMP7 [44, 45] . Current tools to support research in this field include animal models, cell lines such as the AEII cell line A549, non-epithelial models, as well as primary human bronchial epithelial, airway and alveolar epithelial cells [46] [47] [48] [49] [50] . However, the limited replicative lifespan of the latter cell types still remains a technical challenge to investigate these diseases. In this regard, our model might be of value to advance research in this field. However, future studies will be required to determine its applicability for research into lung diseases linked to aberrant regeneration, such as chronic obstructive pulmonary disease or idiophatic pulmonary fibrosis.
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