Author: Imai-Matsushima, Aki; Martin-Sancho, Laura; Karlas, Alexander; Imai, Seiichiro; Zoranovic, Tamara; Hocke, Andreas C.; Mollenkopf, Hans-Joachim; Berger, Hilmar; Meyer, Thomas F.
Title: Long-Term Culture of Distal Airway Epithelial Cells Allows Differentiation Towards Alveolar Epithelial Cells Suited for Influenza Virus Studies Document date: 2018_6_22
ID: vopbw1tl_39
Snippet: By contrast, we found many genes upregulated during default differentiation that have been associated with idiopathic pulmonary fibrosis, e.g. CCL2 [40] , CCL3 [41] , SERPINE2 [42] , [43] and MMP7 [44, 45] . Current tools to support research in this field include animal models, cell lines such as the AEII cell line A549, non-epithelial models, as well as primary human bronchial epithelial, airway and alveolar epithelial cells [46] [47] [48] [49] .....
Document: By contrast, we found many genes upregulated during default differentiation that have been associated with idiopathic pulmonary fibrosis, e.g. CCL2 [40] , CCL3 [41] , SERPINE2 [42] , [43] and MMP7 [44, 45] . Current tools to support research in this field include animal models, cell lines such as the AEII cell line A549, non-epithelial models, as well as primary human bronchial epithelial, airway and alveolar epithelial cells [46] [47] [48] [49] [50] . However, the limited replicative lifespan of the latter cell types still remains a technical challenge to investigate these diseases. In this regard, our model might be of value to advance research in this field. However, future studies will be required to determine its applicability for research into lung diseases linked to aberrant regeneration, such as chronic obstructive pulmonary disease or idiophatic pulmonary fibrosis.
Search related documents:
Co phrase search for related documents- cell line and epithelial cell: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75
- cell line and field research: 1, 2, 3
- cell line and future study: 1, 2, 3, 4, 5
- cell line and human bronchial epithelial: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29
- cell line and idiopathic pulmonary fibrosis: 1
- cell line and lung disease: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11
- cell line and obstructive pulmonary disease: 1, 2, 3
- cell line and pulmonary disease: 1, 2, 3, 4, 5, 6, 7
- cell line and pulmonary fibrosis: 1, 2, 3, 4, 5, 6, 7
- cell line and research advance: 1, 2
- cell type and disease investigate: 1, 2
- cell type and epithelial cell: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74
- cell type and field research: 1, 2
- cell type and future study: 1, 2, 3, 4
- cell type and human bronchial epithelial: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13
- cell type and idiopathic pulmonary fibrosis: 1, 2, 3, 4, 5, 6
- cell type and lung disease: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27
- cell type and obstructive pulmonary disease: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16
- cell type and primary alveolar airway human bronchial epithelial: 1
Co phrase search for related documents, hyperlinks ordered by date