Author: Liu, Yan-Cun; Zou, Xian-Biao; Chai, Yan-Fen; Yao, Yong-Ming
Title: Macrophage Polarization in Inflammatory Diseases Document date: 2014_5_1
ID: u1io62e3_38
Snippet: Therapeutic targeting of macrophage polarization is in its infancy [22] . CCL2 inhibitors (a human study in vitro) and anti-CSF-1 antibodies (a study in mouse models) were shown to promote M2-like skewing of macrophage function to suppress tumor growth [93, 94] , although their primary effects were blockers of monocyte and macrophage recruitment. PPARγ is a key molecule of M2 polarization in diabetes and obesity [95] , and PPARγ inhibitors coul.....
Document: Therapeutic targeting of macrophage polarization is in its infancy [22] . CCL2 inhibitors (a human study in vitro) and anti-CSF-1 antibodies (a study in mouse models) were shown to promote M2-like skewing of macrophage function to suppress tumor growth [93, 94] , although their primary effects were blockers of monocyte and macrophage recruitment. PPARγ is a key molecule of M2 polarization in diabetes and obesity [95] , and PPARγ inhibitors could decrease M2 polarization and improve insulin sensitivity in mouse adipose tissue which is the basic pathophysiological process of obesity and diabetes [96] . Through down-regulation of PIGF, it was reported that HRG polarized mouse TAM to M1-like and inhibited tumor growth as well as metastasis [82] . CD40 agonist also plays a potential role as a M1 promoter and increases a remarkable anti-tumor effect in pancreatic carcinoma in mice and humans [97] .
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