Author: Vere Hodge, R Anthony
Title: Meeting report: 30th International Conference on Antiviral Research, in Atlanta, GA, USA Document date: 2018_6_28
ID: tudwns0r_43
Snippet: The fusion inhibitors have also been used to define the stoichiometry for inhibiting E-mediated fusion of virus-like particles (VLPs) using a single-particle fusion assay. In this experimental model, VLPs with 120 copies of E (60 pre-fusion dimers) can be induced to fuse with a supported lipid bilayer upon exposure to acidic pH. Using a derivative of 3-110-22 modified with a fluorophore, binding of 10-12 copies of the inhibitor ($10% of sites) wa.....
Document: The fusion inhibitors have also been used to define the stoichiometry for inhibiting E-mediated fusion of virus-like particles (VLPs) using a single-particle fusion assay. In this experimental model, VLPs with 120 copies of E (60 pre-fusion dimers) can be induced to fuse with a supported lipid bilayer upon exposure to acidic pH. Using a derivative of 3-110-22 modified with a fluorophore, binding of 10-12 copies of the inhibitor ($10% of sites) was shown to be sufficient to prevent viral fusion.
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