Author: Dutilh, Bas E
Title: Metagenomic ventures into outer sequence space Document date: 2014_12_15
ID: ybd8hi8y_7
Snippet: One striking example of a novel genome discovered among the unknown sequences is crAssphage, a bacteriophage whose genome uniquely aligned sequencing reads from 73% of the 466 analyzed human gut metagenomes, and constituted a total of 1.68% of those metagenomic reads. 23 Like many bacteriophages, its genome sequence is highly divergent from everything that was present in the annotated part of the Genbank database, which is why it was not observed.....
Document: One striking example of a novel genome discovered among the unknown sequences is crAssphage, a bacteriophage whose genome uniquely aligned sequencing reads from 73% of the 466 analyzed human gut metagenomes, and constituted a total of 1.68% of those metagenomic reads. 23 Like many bacteriophages, its genome sequence is highly divergent from everything that was present in the annotated part of the Genbank database, which is why it was not observed before. It has been suggested that the unknown fraction of metagenomes is enriched for viral sequences, 8, 24 because viral genomes are thought to evolve more rapidly than the genomes of cellular organisms, allowing them to explore a larger region of sequence space in the same amount of time.
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