Selected article for: "Akt pathway and signaling pathway"
Author: Ma, J; Wan, J; Meng, J; Banerjee, S; Ramakrishnan, S; Roy, S
Title: Methamphetamine induces autophagy as a pro-survival response against apoptotic endothelial cell death through the Kappa opioid receptor
  • Document date: 2014_3_6
    • ID: wu2mogfa_12
    Snippet: METH activates the ERK1/2 pathway and inhibits the Akt/ mTOR pathway. Autophagy is a multi-step process and is highly regulated through the action of various kinases, phosphatases and guanosine triphosphatases(GT-Pases). [22] [23] [24] The following two pathways are known to be important in the regulation of autophagy: (i) The class I phosphatidylinositol 3-phosphate kinase (PI3K)/Akt/ mammalian target of Rapamycin (mTOR)/p70 ribosomal protein S6.....
    Document: METH activates the ERK1/2 pathway and inhibits the Akt/ mTOR pathway. Autophagy is a multi-step process and is highly regulated through the action of various kinases, phosphatases and guanosine triphosphatases(GT-Pases). [22] [23] [24] The following two pathways are known to be important in the regulation of autophagy: (i) The class I phosphatidylinositol 3-phosphate kinase (PI3K)/Akt/ mammalian target of Rapamycin (mTOR)/p70 ribosomal protein S6 kinase (p70S6K) signaling pathway; and (ii) the Ras/Raf-1/mitogen-activated protein kinase 1/2 (MEK1/2)/ extracellular signal-regulated kinase 1/2 (ERK1/2) pathway. 25 Therefore, we examined the upstream mediators that are involved in METH-induced autophagy using western blotting. METH treatment showed a sustained increase in the level of phosphorylated ERK1/2, the active form, visible 6 h post treatment (Figures 4a and b) . METH-induced ERK phosphorylation was inhibited when cells were pretreated with the KOR antagonist nor-BNI establishing the role of KOR in METH-induced autophagy (Figures 4c and d) .

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