Author: Jordan, Paul C; Stevens, Sarah K; Deval, Jerome
Title: Nucleosides for the treatment of respiratory RNA virus infections Document date: 2018_3_21
ID: txaoz7oh_40
Snippet: In this review, we summarized the exciting advances in discovery and development of novel nucleoside analogs as potential new treatments for respiratory RNA virus infections. The medical need is high because very few drugs have been approved for the treatment of respiratory viral infections despite worldwide health impacts attributed to them. The approved drugs include zanamivir, oseltamivir, peramivir, and favipiravir (Japan only) for influenza .....
Document: In this review, we summarized the exciting advances in discovery and development of novel nucleoside analogs as potential new treatments for respiratory RNA virus infections. The medical need is high because very few drugs have been approved for the treatment of respiratory viral infections despite worldwide health impacts attributed to them. The approved drugs include zanamivir, oseltamivir, peramivir, and favipiravir (Japan only) for influenza virus and palivizumab for RSV, all of which have limitations that prevent their widespread use in a therapeutic setting. Drug candidates intended for use against rhinovirus infections, such as the capsid inhibitor pleconaril and the protease inhibitor rupintrivir, have been tested in the clinic without success.
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