Author: Willemsen, Anouk; Zwart, Mark P
Title: On the stability of sequences inserted into viral genomes Document date: 2019_11_14
ID: vv5gpldi_65
Snippet: As a wild example, HIV-1 frequently undergoes genomic rearrangements, where indels are significant source of evolutionary change. These indels appear to have an impact on virus transmission and adaptation as for example indels in the HIV-1 pol gene are associated with drug resistance (Rakik et al. 1999) , and indels in the gag and vif genes are associated with disease progression and infectivity (Alexander et al. 2002; Aralaguppe et al. 2017 ). T.....
Document: As a wild example, HIV-1 frequently undergoes genomic rearrangements, where indels are significant source of evolutionary change. These indels appear to have an impact on virus transmission and adaptation as for example indels in the HIV-1 pol gene are associated with drug resistance (Rakik et al. 1999) , and indels in the gag and vif genes are associated with disease progression and infectivity (Alexander et al. 2002; Aralaguppe et al. 2017 ). The HIV-1 surface envelope glycoprotein contains five variable regions (V1-V5) that can tolerate a higher rate of indels than the rest of the genome. Interestingly, indel rate estimates vary significantly among variable regions and subtypes (from different hosts) (Palmer and Poon 2018).
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