Selected article for: "bioenergetic profile and drug discovery iLINCS connectivity"
Author: Courtney R. Sullivan; Catharine A. Mielnik; Sinead M. O’Donovan; Adam J. Funk; Eduard Bentea; Erica A.K. DePasquale; Zhexing Wen; Vahram Haroutunian; Pavel Katsel; Amy J. Ramsey; Jarek Meller; Robert E. McCullumsmith
Title: Connectivity analyses of bioenergetic changes in schizophrenia: Identification of novel treatments
  • Document date: 2018_6_5
    • ID: ltb6l5xz_92
    Snippet: We began by selecting genes of interest from schizophrenia pathophysiology to build a "bioenergetic schizophrenia profile." We selected targets from the glycolytic pathway that were selectively downregulated in this study and our previous studies (GPI, HK1, PFKM, PFKL), as well as dysregulated in the literature (LDHA, PFKFB2) (Table 1) (14, 15, 18) . Knockdown signatures were retrieved for each seed gene in iLINCS, and these knockdown signatures .....
    Document: We began by selecting genes of interest from schizophrenia pathophysiology to build a "bioenergetic schizophrenia profile." We selected targets from the glycolytic pathway that were selectively downregulated in this study and our previous studies (GPI, HK1, PFKM, PFKL), as well as dysregulated in the literature (LDHA, PFKFB2) (Table 1) (14, 15, 18) . Knockdown signatures were retrieved for each seed gene in iLINCS, and these knockdown signatures were used in subsequent lookup replication, iLINCS clustering (Enrichr), and iLINCS connectivity (drug discovery) analyses.

    Search related documents:
    Co phrase search for related documents
    • bioenergetic schizophrenia profile and glycolytic pathway: 1
    • bioenergetic schizophrenia profile and iLINCS connectivity: 1, 2, 3
    • bioenergetic schizophrenia profile and iLINCS seed gene: 1
    • bioenergetic schizophrenia profile and knockdown signature: 1
    • bioenergetic schizophrenia profile and lookup replication: 1, 2
    • bioenergetic schizophrenia profile and schizophrenia profile: 1, 2, 3, 4, 5, 6, 7, 8
    • bioenergetic schizophrenia profile and seed gene: 1
    • bioenergetic schizophrenia profile and subsequent lookup replication: 1
    • drug discovery iLINCS connectivity and glycolytic pathway: 1
    • drug discovery iLINCS connectivity and iLINCS connectivity: 1, 2, 3, 4, 5
    • drug discovery iLINCS connectivity and lookup replication: 1, 2
    • drug discovery iLINCS connectivity and schizophrenia profile: 1, 2
    • drug discovery iLINCS connectivity and subsequent lookup replication: 1
    • glycolytic pathway and iLINCS connectivity: 1
    • glycolytic pathway and lookup replication: 1
    • glycolytic pathway and schizophrenia profile: 1
    • ilincs cluster and seed gene: 1, 2
    • iLINCS connectivity and schizophrenia profile: 1, 2, 3
    • iLINCS connectivity and seed gene: 1, 2