Author: Chew, Miaw-Fang; Poh, Keat-Seong; Poh, Chit-Laa
Title: Peptides as Therapeutic Agents for Dengue Virus Document date: 2017_10_15
ID: u1opdwmd_22
Snippet: The importance of hydrophobicity was further supported by Hrobowski et al. (2005) , whereby the novel antiviral peptide was successfully identified using the Wimley-White interfacial hydrophobicity scale (WWIHS) screening method. This screening method calculated a sliding hydrophobicity score to determine the segments of the protein with a propensity to interact with membrane interfaces [119] . By using a similar strategy, another study has ident.....
Document: The importance of hydrophobicity was further supported by Hrobowski et al. (2005) , whereby the novel antiviral peptide was successfully identified using the Wimley-White interfacial hydrophobicity scale (WWIHS) screening method. This screening method calculated a sliding hydrophobicity score to determine the segments of the protein with a propensity to interact with membrane interfaces [119] . By using a similar strategy, another study has identified five hydrophobic regions located on the DENV-2 E protein [122] . Amino acids derived from these regions were screened via WWIHS and further optimized using RAPDF biased Monte Carlo method. This resulted in the identification of several novel peptides, namely DS03/DS04, DS27/DS28 and DS36, which could potentially interrupt protein-protein interactions during DENV fusion. Likewise, many antiviral peptides were identified against other viruses such as type-1 herpes simplex virus (HSV-1) [122] , severe acute respiratory syndrome coronavirus (SARS) [123] , human cytomegalovirus (HCMV) [124] and rift valley fever virus (RVFV) [125] via the same approach. This again has validated the importance of hydrophobicity property for antiviral peptides.
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