Author: Chew, Miaw-Fang; Poh, Keat-Seong; Poh, Chit-Laa
Title: Peptides as Therapeutic Agents for Dengue Virus Document date: 2017_10_15
ID: u1opdwmd_23
Snippet: In addition, it was observed that many of the antiviral peptides known to inhibit entry of enveloped viruses to cells have hydrophobic and/or amphipathic properties to facilitate the interaction with cellular lipid membrane interfaces [126, 127] . Besides using WWIHS, the interfacial helical hydrophobic moment (iHHM) is another physio-chemical determining strategy which can be used to augment the peptide-membrane interfaces. This approach quantif.....
Document: In addition, it was observed that many of the antiviral peptides known to inhibit entry of enveloped viruses to cells have hydrophobic and/or amphipathic properties to facilitate the interaction with cellular lipid membrane interfaces [126, 127] . Besides using WWIHS, the interfacial helical hydrophobic moment (iHHM) is another physio-chemical determining strategy which can be used to augment the peptide-membrane interfaces. This approach quantified the segregation of hydrophobic and hydrophilic faces of a peptide folded into an α-helix structure [128] . Higher iHHM value indicates stronger membrane interaction with peptides [129, 130] . Additionally, Badani et al. (2014) also suggested hydrophobicity and amphipathicity to be critical properties for peptides in their interaction with cellular membrane and thereby inhibiting viral entry [126] . Therefore, for future drug design and development, researchers could consider incorporating the hydrophobic and amphipathic properties into antiviral peptides to further enhance antiviral efficacies.
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