Selected article for: "peripheral blood and present study"
Author: LI, Xunliang; LI, Pengchong; CAO, Liyan; BAI, Yunyun; CHEN, Huijie; LIU, He; REN, Xiaofeng; LI, Guangxing
Title: Porcine IL-12 plasmid as an adjuvant improves the cellular and humoral immune responses of DNA vaccine targeting transmissible gastroenteritis virus spike gene in a mouse model
  • Document date: 2019_9_2
    • ID: rme6b022_42
    Snippet: CTLs directly destroy infected cells, and recognize the major histocompatibility complex I/antigen complexes. CTLs lyse target cells through the release of cytolytic granules, and the surfaces of these cells express the Fas ligand [7] . CTL activity is assessed using the change in LDH levels [4, 8] . CTLs and neutralizing antibodies directly act on viruses and protect the host from viral infection [25] . In the present study, pVAX1-(TGEV-S1) comb.....
    Document: CTLs directly destroy infected cells, and recognize the major histocompatibility complex I/antigen complexes. CTLs lyse target cells through the release of cytolytic granules, and the surfaces of these cells express the Fas ligand [7] . CTL activity is assessed using the change in LDH levels [4, 8] . CTLs and neutralizing antibodies directly act on viruses and protect the host from viral infection [25] . In the present study, pVAX1-(TGEV-S1) combined with pVAX1-(pIL-12) exerted positive effects on the activation of CTLs both in the blood and spleen and showed a marked advantage over pVAX1-(TGEV-S1) alone, especially in the peripheral blood.

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