Author: Bird, Grace; Braithwaite, Irene; Harper, James; McKinstry, Steven; Koorevaar, Iris; Fingleton, James; Semprini, Alex; Dilcher, Meik; Jennings, Lance; Weatherall, Mark; Beasley, Richard
Title: Protocol for a randomised, single-blind, two-arm, parallel-group controlled trial of the efficacy of rhinothermy delivered by nasal high flow therapy in the treatment of the common cold Document date: 2019_6_19
ID: x2xc1s14_79
Snippet: In our recent randomised control trial of rNHF compared to Vitamin C a 5-unit reduction in MJS represented a substantial clinical benefit. [16] The upper confidence limit for the standard deviation in this trial was 6.6. A sample size of 76 in each group allows the detection of a difference of 3.5 units, with 90% power and a Type I error rate of 5%. Allowing for a 10% dropout rate, a total of 85 participants will be randomised to each group......
Document: In our recent randomised control trial of rNHF compared to Vitamin C a 5-unit reduction in MJS represented a substantial clinical benefit. [16] The upper confidence limit for the standard deviation in this trial was 6.6. A sample size of 76 in each group allows the detection of a difference of 3.5 units, with 90% power and a Type I error rate of 5%. Allowing for a 10% dropout rate, a total of 85 participants will be randomised to each group.
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