Author: Chan, Joseph M.; Rabadan, Raul
Title: Quantifying Pathogen Surveillance Using Temporal Genomic Data Document date: 2013_1_29
ID: u2t1x89m_30
Snippet: We applied this measure to multiple influenza virus strains and found that current surveillance is generally complete for humans, particularly H1N1pdm, H3N2, and seasonal H1N1, but poor for other hosts, particularly swine. Indeed, the calculated q2 coefficient of swine H1N1 is most likely an overestimate, considering that influenza virus evolves more slowly in swine than in humans because of a lesser degree of immune selection (42) . This finding.....
Document: We applied this measure to multiple influenza virus strains and found that current surveillance is generally complete for humans, particularly H1N1pdm, H3N2, and seasonal H1N1, but poor for other hosts, particularly swine. Indeed, the calculated q2 coefficient of swine H1N1 is most likely an overestimate, considering that influenza virus evolves more slowly in swine than in humans because of a lesser degree of immune selection (42) . This finding reaffirms the need for increased surveillance of swine, which can serve as mixing vessels for pandemic strain selection.
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