Author: Rogers, J.; Schoepp, R.J.; Schröder, O.; Clements, T.L.; Holland, T.F.; Li, J.Q.; Li, J.; Lewis, L.M.; Dirmeier, R.P.; Frey, G.J.; Tan, X.; Wong, K.; Woodnutt, G.; Keller, M.; Reed, D.S.; Kimmel, B.E.; Tozer, E.C.
Title: Rapid discovery and optimization of therapeutic antibodies against emerging infectious diseases Document date: 2008_5_13
ID: xkx56h0o_66
Snippet: Because of the potential for improved neutralization capability with higher affinity antibodies, we attempted to increase the affinity of the top antibody variant using GSSM methodology. However, this methodology is not limited to affinity improvements and can be used to evolve many different properties such as specificity, protein expression, stability, folding, etc. As it is impossible to sample all of the sequence space within a given protein .....
Document: Because of the potential for improved neutralization capability with higher affinity antibodies, we attempted to increase the affinity of the top antibody variant using GSSM methodology. However, this methodology is not limited to affinity improvements and can be used to evolve many different properties such as specificity, protein expression, stability, folding, etc. As it is impossible to sample all of the sequence space within a given protein (i.e. 20 100 for a 100 amino acid protein), this methodology allows one to systematically sample for 'hot spots' within the protein, which can then be combined together and evaluated at a higher resolution in areas of interest.
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