Author: Lan, Jiaming; Yao, Yanfeng; Deng, Yao; Chen, Hong; Lu, Guangwen; Wang, Wen; Bao, Linlin; Deng, Wei; Wei, Qiang; Gao, George F.; Qin, Chuan; Tan, Wenjie
Title: Recombinant Receptor Binding Domain Protein Induces Partial Protective Immunity in Rhesus Macaques Against Middle East Respiratory Syndrome Coronavirus Challenge() Document date: 2015_8_18
ID: q8i2gfut_41
Snippet: Virus titres of various tissues and swabs of immunised animals were determined by end-point titration in Vero cells. Viral loads in the lungs and trachea of control monkeys were as high as 50 and 100 TCID 50 /mL, respectively (Table 2 ), but rRBD-immunised monkeys could not isolate MERS-CoV from the lungs. Although MERS-CoV could be isolated from two of the six rRBD-immunised monkeys, virus titres were lower vs. the mock group......
Document: Virus titres of various tissues and swabs of immunised animals were determined by end-point titration in Vero cells. Viral loads in the lungs and trachea of control monkeys were as high as 50 and 100 TCID 50 /mL, respectively (Table 2 ), but rRBD-immunised monkeys could not isolate MERS-CoV from the lungs. Although MERS-CoV could be isolated from two of the six rRBD-immunised monkeys, virus titres were lower vs. the mock group.
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