Selected article for: "Coronavirus disease and SARS infection"
Author: Totura, Allison L.; Baric, Ralph S.
Title: Reply to “Statins may decrease the Fatality Rate of MERS Infection”
  • Document date: 2015_9_29
    • ID: tle5jvak_4
    Snippet: MyD88 signaling was largely repressed by the use of statins in MERS patients, this could lead to exacerbated compensatory signaling by other innate immune factors, resulting in a poor disease outcome in coronavirus patients. Of critical importance is that the absence of these central TLR adaptor molecules results in increased viral loads that persist for longer periods of time than in wild-type mice following SARS-CoV or MERS-CoV infection (7, 13.....
    Document: MyD88 signaling was largely repressed by the use of statins in MERS patients, this could lead to exacerbated compensatory signaling by other innate immune factors, resulting in a poor disease outcome in coronavirus patients. Of critical importance is that the absence of these central TLR adaptor molecules results in increased viral loads that persist for longer periods of time than in wild-type mice following SARS-CoV or MERS-CoV infection (7, 13, 14) . Currently, high viral titers during the acute phase of infection are thought to be a potential factor that increases the likelihood of person-to-person transmission of highly pathogenic coronaviruses. Caution must be used when weighing potential therapeutic options that may increase the likelihood of the spread of these viruses.

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