Author: Tang, Hei-Man Vincent; Gao, Wei-Wei; Chan, Chi-Ping; Cheng, Yun; Chaudhary, Vidyanath; Deng, Jian-Jun; Yuen, Kit-San; Wong, Chun-Ming; Ng, Irene Oi-Lin; Kok, Kin-Hang; Zhou, Jie; Jin, Dong-Yan
Title: Requirement of CRTC1 coactivator for hepatitis B virus transcription Document date: 2014_11_10
ID: qtoygz6w_49
Snippet: HBx activates HBV and cellular gene expression through multiple mechanisms. Particularly, HBx stimulates CREBdependent transcription by cooperating with p300/CBP coactivators (20) , promoting CREB dimerization (21) and inhibiting negative regulators (41) . Our documentation of the interaction and mutual stabilization of HBx and CRTC1/2 ( Figures 6 and 7 ) provides a new mechanism by which HBx regulates HBV transcription. Since CRTCs are essential.....
Document: HBx activates HBV and cellular gene expression through multiple mechanisms. Particularly, HBx stimulates CREBdependent transcription by cooperating with p300/CBP coactivators (20) , promoting CREB dimerization (21) and inhibiting negative regulators (41) . Our documentation of the interaction and mutual stabilization of HBx and CRTC1/2 ( Figures 6 and 7 ) provides a new mechanism by which HBx regulates HBV transcription. Since CRTCs are essential coactivators of CREB-dependent transcription of both HBV and cellular promoters, HBx might also modulate cellular CRE-dependent promoters through its interaction and stabilization of CRTC1/2.
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