Title: Research Communications of the 24th ECVIM-CA Congress Document date: 2015_1_10
ID: r59usk02_401
Snippet: No conflicts of interest reported. Alpha 1 -proteinase inhibitor (a 1 -PI) is a proteinase-resistent protein that can be quantified in fecal, urine, and serum samples from dogs. Recently, increased fecal and urinary canine a 1 -PI (ca 1 -PI) concentrations have been described in dogs with gastrointestinal diseases (e.g., inflammatory bowel disease [IBD] , but also in dogs with exocrine pancreatic insufficiency) and in dogs with chronic hepatitis .....
Document: No conflicts of interest reported. Alpha 1 -proteinase inhibitor (a 1 -PI) is a proteinase-resistent protein that can be quantified in fecal, urine, and serum samples from dogs. Recently, increased fecal and urinary canine a 1 -PI (ca 1 -PI) concentrations have been described in dogs with gastrointestinal diseases (e.g., inflammatory bowel disease [IBD] , but also in dogs with exocrine pancreatic insufficiency) and in dogs with chronic hepatitis or chronic kidney disease, respectively. Decreased serum ca 1 -PI concentrations have been reported in dogs with IBD, protein-losing enteropathy (PLE), and hypocobalaminemia. Treatment protocols for dogs with IBD and/or PLE commonly include corticosteroids, but the effect of corticosteroid therapy on serum ca 1 -PI concentrations have not yet been reported. The aim of this study was to evaluate the effect of hydro-cortisone on serum ca 1 -PI concentrations in healthy dogs.
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