Title: Research Communications of the 24th ECVIM-CA Congress Document date: 2015_1_10
ID: r59usk02_51
Snippet: No conflicts of interest reported. MicroRNAs (miRNA) are short (19-22 nucleotides), singlestranded, non-coding RNAs that specifically anneal with complementary sequences in multiple mRNA targets, and they silence mRNAs and suppress downstream protein translation. A miRNA can act as a fine-tuner of gene expression or an on/off switch. These features highlight the potential of miR-NAs as therapeutic targets. The role of miRNAs in myocardial fibrosi.....
Document: No conflicts of interest reported. MicroRNAs (miRNA) are short (19-22 nucleotides), singlestranded, non-coding RNAs that specifically anneal with complementary sequences in multiple mRNA targets, and they silence mRNAs and suppress downstream protein translation. A miRNA can act as a fine-tuner of gene expression or an on/off switch. These features highlight the potential of miR-NAs as therapeutic targets. The role of miRNAs in myocardial fibrosis and hypertrophic cardiomyopathy has been widely studied in human patients. However, there is no data available for canine and human myxomatous mitral valve disease (MMVD). The aim of this study was to investigate miRNA transcriptomics in canine MMVD by using global transcriptional profiling, miRNA target prediction software (DIANA Tool, TargetScan 6.2) and network analysis software (BioLayout Express 3D ).
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