Title: Research Communications of the 27(th) ECVIM-CA Congress: Intercontinental, Saint Julian's, Malta, 14th to 16th September 2017 Document date: 2017_11_7
ID: roslkxeq_307
Snippet: Disclosures: No disclosures to report. Dogs with naturally occurring parvovirus infection may be at risk of developing acute kidney injury due to several risk factors, including severe dehydration, systemic inflammatory response syndrome, and sepsis. Early detection of kidney injury is important, yet challenging, because conventional renal parameters, such as serum creatinine (sCr) and blood urea nitrogen (BUN), are insensitive markers for early .....
Document: Disclosures: No disclosures to report. Dogs with naturally occurring parvovirus infection may be at risk of developing acute kidney injury due to several risk factors, including severe dehydration, systemic inflammatory response syndrome, and sepsis. Early detection of kidney injury is important, yet challenging, because conventional renal parameters, such as serum creatinine (sCr) and blood urea nitrogen (BUN), are insensitive markers for early stages of kidney injury and dysfunction. Therefore, the aim of this study was to investigate potential kidney injury in dogs with naturally occurring parvoviral infection by comparing standard to novel urinary biomarkers. Twenty-two dogs with parvoviral infection were prospectively enrolled and compared with eight clinically healthy control dogs. Blood and urine samples were collected at presentation (T 0 ) in both groups and 24 h later (T 1 ) in the patient group. Urinary immunoglobulin G (uIgG) and C-reactive protein (uCRP) were measured to document glomerular injury, whereas urinary retinolbinding protein (uRBP) and neutrophil gelatinase-associated lipocalin (uNGAL) served as biomarkers for tubular injury. These biomarkers were compared to routine renal functional parameters, including sCr, BUN, urinary protein:creatinine ratio (UPC), and urine specific gravity (USG). Commercial ELISAs validated for the measurement of canine uIgG, uCRP, uRBP, and uNGAL were used. Statistical analysis was performed using non-parametric Mann-Whitney and Wilcoxon signed rank tests.
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