Title: Research Communications of the 27(th) ECVIM-CA Congress: Intercontinental, Saint Julian's, Malta, 14th to 16th September 2017 Document date: 2017_11_7
ID: roslkxeq_402
Snippet: This study demonstrates that p21 expression in normal dogs increases with age as expected but is upregulated in CCH, indicating a state of cellular senescence irrespective of age. The median percentage of senescent hepatocytes in CCH was higher than in human hepatitis. These cells are indistinguishable from normal hepatocytes using routine stains but are unable to perform normal hepatic functions. p21 quantification in CCH may therefore provide a.....
Document: This study demonstrates that p21 expression in normal dogs increases with age as expected but is upregulated in CCH, indicating a state of cellular senescence irrespective of age. The median percentage of senescent hepatocytes in CCH was higher than in human hepatitis. These cells are indistinguishable from normal hepatocytes using routine stains but are unable to perform normal hepatic functions. p21 quantification in CCH may therefore provide additional information regarding hepatic function. Furthermore, a negative correlation between p21 expression and survival was identified, suggesting a role for p21 quantification in determining prognosis in CCH.
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