Author: Wei Zhen; Ryhana Manji; Elizabeth Smith; Gregory J Berry
Title: Comparison of Four Molecular In Vitro Diagnostic Assays for the Detection of SARS-CoV-2 in Nasopharyngeal Specimens Document date: 2020_4_22
ID: 2bf3xzni_1
Snippet: transmitted through several different routes, including aerosol and fecal-to-oral, with fomites often 48 playing an important role in the infection cycle (5). Notably, coronaviruses possess a distinctive 49 morphological feature, a ring of spike proteins on the outer surface of the virus, giving the appearance of 50 a halo or corona. In addition to inspiring the name of the coronavirus genus, the spike proteins are also 51 essential for infection.....
Document: transmitted through several different routes, including aerosol and fecal-to-oral, with fomites often 48 playing an important role in the infection cycle (5). Notably, coronaviruses possess a distinctive 49 morphological feature, a ring of spike proteins on the outer surface of the virus, giving the appearance of 50 a halo or corona. In addition to inspiring the name of the coronavirus genus, the spike proteins are also 51 essential for infection of host cells. The SARS-CoV-2 spike protein recognizes and binds to the human 52 cellular receptor angiotensin-converting enzyme 2 (ACE2), then subsequently mediates fusion of the viral 53 and host cell membranes, allowing the virus to gain entry (6, 7). The ACE2 receptor is found on epithelial 54 cells of the lungs and small intestines (8). 55 All rights reserved. No reuse allowed without permission. author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
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