Research Communications of the 27(th) ECVIM-CA Congress: Intercontinental, Saint Julian's, Malta, 14th to 16th September 2017

Disclosures: Disclosures to report. Study planned, organized and financed by Boehringer Ingelheim. Gastroduodenal ulceration is a recognized complication of NSAID or corticosteroid therapy, liver disease, sepsis, and neoplasia. Retrospective studies indicate that male, middle-aged and large breed dogs are most commonly affected. Rottweilers were affected at younger ages. Helicobacter has been associated with chronic gastritis; its effect on gastric mucosal barrier function (GMBF) is unknown. Previous Using chamber ex vivo injury models have examined changes in GMBF that relate to ulcer injury in vivo. Identification of factors associated with GMBF, as measured by transepithelial electrical resistance (TER), could identify risk factors for gastroduodenal ulceration in vivo. In this prospective study, TER was measured in control and acid-injured canine tissue to determine factors associated with changes in GMBF. These included: age, sex, neuter status, breed (large/small), and presence/ degree of Helicobacter infection.