Author: Chen, Yongxiong; Chan, Vera Sau-Fong; Zheng, Bojian; Chan, Kelvin Yuen-Kwong; Xu, Xiaoning; To, Leo Yuk-Fai; Huang, Fang-Ping; Khoo, Ui-Soon; Lin, Chen-Lung Steve
Title: A novel subset of putative stem/progenitor CD34(+)Oct-4(+) cells is the major target for SARS coronavirus in human lung Document date: 2007_10_29
ID: u4qhk802_16
Snippet: In the ex vivo -infected samples where SARS Ï© cells were detected, an average of about two to three SARS Ï© cells per tissue section could be identifi ed. The reason for few cells being infected in this model is unclear. One possibility is that, unlike the in vivo situation where the virus can reside and replicate in the lung for days to weeks, fresh lung tissues in the form of blocks were exposed to live virus for 16 h only. Thus, the virus may.....
Document: In the ex vivo -infected samples where SARS Ï© cells were detected, an average of about two to three SARS Ï© cells per tissue section could be identifi ed. The reason for few cells being infected in this model is unclear. One possibility is that, unlike the in vivo situation where the virus can reside and replicate in the lung for days to weeks, fresh lung tissues in the form of blocks were exposed to live virus for 16 h only. Thus, the virus may not be able to " see " all of these target cells. It is also possible and remains to be investigated if these putative stem/progenitor cells represent a heterogeneous population that is still diff erentiating and only cells at a certain diff erentiation stage are susceptible to the viral infection.
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