Selected article for: "infect mouse and type mouse"
Author: Chen, Yongxiong; Chan, Vera Sau-Fong; Zheng, Bojian; Chan, Kelvin Yuen-Kwong; Xu, Xiaoning; To, Leo Yuk-Fai; Huang, Fang-Ping; Khoo, Ui-Soon; Lin, Chen-Lung Steve
Title: A novel subset of putative stem/progenitor CD34(+)Oct-4(+) cells is the major target for SARS coronavirus in human lung
  • Document date: 2007_10_29
    • ID: u4qhk802_5
    Snippet: Our fi ndings indicate that SARS-infected cells are unlikely to be pneumocytes (either type 1 or type 2) or cytokeratin Ï© epithelial cells. This observation is supported by a recent report that SARS-CoV cannot infect or replicate in the fully diff erentiated mouse type 1 or type 2 pneumocytes ( 14 ) . Our result does contradict some data in the literature that suggest that cytokeratin Ï© , surfactant Ï© , or the epithelial membrane antigenexpres.....
    Document: Our fi ndings indicate that SARS-infected cells are unlikely to be pneumocytes (either type 1 or type 2) or cytokeratin Ï© epithelial cells. This observation is supported by a recent report that SARS-CoV cannot infect or replicate in the fully diff erentiated mouse type 1 or type 2 pneumocytes ( 14 ) . Our result does contradict some data in the literature that suggest that cytokeratin Ï© , surfactant Ï© , or the epithelial membrane antigenexpressing pneumocytes are targeted by SARS-CoV ( 6 -12 ) . Upon reviewing the literature, however, we noticed that in is in the right column. Isotype antibody control for IHC and immunofl uorescence is in g and h, respectively. Some SARS Ï© cells were actually " overlapping " with adjacent cytokeratin Ï© cells (one indicated by a circle in k), which might be mistakenly regarded " colocalized " on two-dimensional photos. Panels of each row represent results of the same section from a patient. Results are representative of six SARS patients who died within 11 d after disease onset. Bar, 20 m.

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