Title: RESEARCH COMMUNICATIONS OF THE 28th ECVIM-CA CONGRESS Document date: 2018_12_19
ID: r79h9yzz_1209
Snippet: Naloxonâ€fluoresceinâ€stained flowâ€cytometric analysis revealed the presence of opioid receptors in the cTCC cell line. The receptor density increased mildly upon 24 hours pretreatment with doxorubicin. As intended, methadon given at a dose of 3μg/ml did not inhibit proliferation. Doxorubicin at 0.5μg/ml inhibited proliferation at all timeâ€points. When cells were pretreated with doxorubicin, and methadone added after 24 hours, no potentia.....
Document: Naloxonâ€fluoresceinâ€stained flowâ€cytometric analysis revealed the presence of opioid receptors in the cTCC cell line. The receptor density increased mildly upon 24 hours pretreatment with doxorubicin. As intended, methadon given at a dose of 3μg/ml did not inhibit proliferation. Doxorubicin at 0.5μg/ml inhibited proliferation at all timeâ€points. When cells were pretreated with doxorubicin, and methadone added after 24 hours, no potentiation took place. Conversely, when methadone was given 24 hours before doxorubicin, a tendency of potentiation of doxorubicin's inhibitory effect on proliferation was found.
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