RESEARCH COMMUNICATIONS OF THE 28th ECVIM-CA CONGRESS

CTVT is a frequent tumor in dogs in Ukraine without age, sex and breed predisposition. CTVT is most often transmitted by sexual contact and affects the genitals. Extragenital CTVT can be located on the skin, in the nasal and oral cavity, metastasize lungs and regional lymph nodes. The largest previously published study of nasal CTVT included an analysis of 6 cases. The aim of the study was to analyze and describe the clinical manifestations and response to therapy in patients with the nasal form of CTVT. 11 dogs with a naturally occurring CTVT were included in a retrospective study. Patients entered treatment from different regions of Ukraine and received therapy at the Zoovetservis clinic in Kiew in 2013‐2017. All patients entered with visualized neoplasms, the diagnosis was made on the basis of cytological (in 4 cases additionally histology) investigations. 8 males and 3 females were included in the study. All of them were not neutered at the time of CTVT detection. None of the patients had genital CTVT lesions, 3 patients had owner, 8 stray dogs had guardians, 2 dogs were breed (bichon, spaniel), 9 dogs were mixbreed. The clinical symptoms of nasal TVT included: sneezing, epistaxis, unilateral or bilateral purulent hemorrhagic discharge from the nose (in all 11 patients), hard skull infiltration and the formation of oronosal fistulas were observed in 9 of 11 patients. In 5 patients, skin fistulas were observed on the back of the nose, all of them spontaneously disappeared after treatment with CTVT. None of the patients had a CTVT planum nasals lesion. All dogs received monochemotherapy with vincristine weekly at a dosage of 0.7 mg / m2. The course consisted of 4‐9 cycles. In patients with oronasal fistulas sneezing and discharge were maintained until the resolution of fistulas with negative cytological control. None of the patients had hematologic toxicity requiring the transfer of chemotherapy. 11 dogs responded to therapy with complete clinical remission. In 10 dogs a year later there was no relapse. There is no information about one dog (3 months after the treatment there was no relapse).