RESEARCH COMMUNICATIONS OF THE 28th ECVIM-CA CONGRESS

A randomized, double‐blinded, placebo‐controlled cross‐over with an 8‐week washout was performed using 24 healthy research dogs. After a 1‐week baseline period, dogs received enrofloxacin (10mg/kg qd) and metronidazole (12.5mg/kg BID) with food for 3 weeks. One hour after each dose of antibiotics, dogs were administered placebos or synbiotics (Proviable®‐Forte with Proviable®‐SB). Mean food intake; days of hyporexia (food intake<50%), vomiting, or diarrhea (fecal score ≥6); and mean fecal score (1‐7) per week were compared between groups using mixed model, repeated measure, cross‐over ANOVAs. P<0.05 was considered significant.