Author: Rappuoli, Rino; Bottomley, Matthew J.; D’Oro, Ugo; Finco, Oretta; De Gregorio, Ennio
Title: Reverse vaccinology 2.0: Human immunology instructs vaccine antigen design Document date: 2016_4_4
ID: uyoerxvu_30
Snippet: In a study by Dosenovic et al. (2015) , eOD-GT8 and Env trimers were also used to immunize a different knock-in mouse strain expressing the mature heavy chain of the human VRC01 NAbs, containing all naturally raised somatic mutations that would pair with a naive λ chain from the mouse repertoire. In this mouse strain, eOD-GT8 was not efficient in triggering NAb responses, whereas Env trimers triggered a robust cross-neutralizing Ab response thro.....
Document: In a study by Dosenovic et al. (2015) , eOD-GT8 and Env trimers were also used to immunize a different knock-in mouse strain expressing the mature heavy chain of the human VRC01 NAbs, containing all naturally raised somatic mutations that would pair with a naive λ chain from the mouse repertoire. In this mouse strain, eOD-GT8 was not efficient in triggering NAb responses, whereas Env trimers triggered a robust cross-neutralizing Ab response through the selection of appropriate mouse light chains.
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