Author: Byszewska, Magdalena; Smietanski, Miroslaw; Purta, Elzbieta; Bujnicki, Janusz M
Title: RNA methyltransferases involved in 5' cap biosynthesis Document date: 2015_1_27
ID: sz2531mv_22
Snippet: In recent years significant progress has been made in understanding the mechanism of formation of different RNA cap structures. This progress has been driven in particular by the identification and characterization of novel methyltransferases that take part in cap biosynthesis, and by the determination of their crystal structures. This knowledge also has a practical dimension, as the capping process is essential for eukaryotic cells as well as fo.....
Document: In recent years significant progress has been made in understanding the mechanism of formation of different RNA cap structures. This progress has been driven in particular by the identification and characterization of novel methyltransferases that take part in cap biosynthesis, and by the determination of their crystal structures. This knowledge also has a practical dimension, as the capping process is essential for eukaryotic cells as well as for the life cycle of viruses that infect them. In this context, the difference between the structures of the human enzymes and the enzymes from human pathogens could be exploited to develop new drugs. In particular, viruses that evolved alternative enzymes to synthesize the same cap structures as are synthesized by human cellular machinery are attractive targets for the development of inhibitors that could specifically block viral methyltransferases.
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