Author: Jeang, Kuan-Teh; Yedavalli, Venkat
Title: Role of RNA helicases in HIV-1 replication Document date: 2006_8_25
ID: vefs1h6o_25
Snippet: In a separate perspective, virus infection can trigger through double-stranded viral RNAs an innate antiviral immune response. Thus viral dsRNAs can be recognized by cellular proteins [pattern-recognition receptors (PRRs)] which initiate antiviral responses by inducing the production of a variety of cytokines including type I interferons (IFN-a and IFN-b) and initiating additional inflammatory and adaptive immune responses. Recently, DExD/H RNA h.....
Document: In a separate perspective, virus infection can trigger through double-stranded viral RNAs an innate antiviral immune response. Thus viral dsRNAs can be recognized by cellular proteins [pattern-recognition receptors (PRRs)] which initiate antiviral responses by inducing the production of a variety of cytokines including type I interferons (IFN-a and IFN-b) and initiating additional inflammatory and adaptive immune responses. Recently, DExD/H RNA helicases such as RIG-1 (retinoic acid inducible gene-1) (93) and Mda5 (melanoma differentiation-associated gene 5) (94) have been identified as suppressors of viral replication by binding to virus associated dsRNA and activating type I interferon-dependent antiviral immunity. Over-expression of RIG-1 and Mda5 was found to enhance dsRNA induced type I interferon antiviral response. Currently, it remains speculative whether helicases like RIG-1 and Mda5 may recognize HIV-1 dsRNA and trigger an innate immune response. Intriguingly, several reports exist in the literature that HIV-1 infection does induce activation of type 1 interferons (95, 96) .
Search related documents:
Co phrase search for related documents- adaptive inflammatory immune response and innate immune response: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15
- antiviral immune response and immune response: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- antiviral immune response and induced type: 1, 2, 3, 4, 5, 6, 7
- antiviral immune response and innate antiviral immune response: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- antiviral immune response and innate immune response: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- antiviral immune response and innate immune response trigger: 1, 2
- antiviral immune response and interferon antiviral response: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15
- antiviral immune response and melanoma differentiation: 1, 2, 3, 4
- antiviral immunity and immune response: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- antiviral immunity and induced type: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15
- antiviral immunity and innate antiviral immune response: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13
- antiviral immunity and innate immune response: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- antiviral immunity and innate immune response trigger: 1
- antiviral immunity and interferon antiviral response: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14
- antiviral immunity and melanoma differentiation: 1, 2, 3, 4
- antiviral response and innate immune response: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- antiviral response and innate immune response trigger: 1, 2, 3
- antiviral response and interferon antiviral response: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- antiviral response and melanoma differentiation: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12
Co phrase search for related documents, hyperlinks ordered by date