Author: Dziwenka, Margitta; Coppock, Robert; Alexander, McCorkle; Palumbo, Eddie; Ramirez, Carlos; Lermer, Stephen
Title: Safety Assessment of a Hemp Extract using Genotoxicity and Oral Repeat-Dose Toxicity Studies in Sprague-Dawley Rats Document date: 2020_2_20
ID: u9msvq70_43
Snippet: Vacuolization of the zona fasciculata at the same incidence and severity was observed in the adrenal glands of treatment and control (Groups 1 and 4) male rats and correlated with an increase in the weights of the adrenal glands. In addition, a statistically significant increase (p < 0.05) in adrenal-to-body weight ratios was observed for Group 4 females that did not correlate with any adrenal histopathology......
Document: Vacuolization of the zona fasciculata at the same incidence and severity was observed in the adrenal glands of treatment and control (Groups 1 and 4) male rats and correlated with an increase in the weights of the adrenal glands. In addition, a statistically significant increase (p < 0.05) in adrenal-to-body weight ratios was observed for Group 4 females that did not correlate with any adrenal histopathology.
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