Title: Susceptibility to cytotoxic T lymphocyte-induced apoptosis is a function of the proliferative status of the target Document date: 1994_2_1
ID: s0bfhwtn_2
Snippet: In a previous investigation (5) , we demonstrated that specific inhibitors for DNA topoisomerases I (camptothecin) and II (mAMSA and VM-26) prevent the CTL-induced DNA fragmentation of the target cell's DNA without impairing the disruption of the target cell's plasma membrane. DNA topoisomerases are cdl cycle-regulated enzymes with low to undetectable activity in early G1 and peak activity in the S and GO/M phases of the cell cycle (6) . We there.....
Document: In a previous investigation (5) , we demonstrated that specific inhibitors for DNA topoisomerases I (camptothecin) and II (mAMSA and VM-26) prevent the CTL-induced DNA fragmentation of the target cell's DNA without impairing the disruption of the target cell's plasma membrane. DNA topoisomerases are cdl cycle-regulated enzymes with low to undetectable activity in early G1 and peak activity in the S and GO/M phases of the cell cycle (6) . We therefore, sought to determine whether the susceptibility of target cells to CTLinduced apoptosis was cdl cycle-related and show here that it is.
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