Author: Zhang, LiuYan; Chang, SuHua; Wang, Jing
Title: Synthetic biology: From the first synthetic cell to see its current situation and future development Document date: 2011_1_26
ID: ychvxsxn_20
Snippet: One of the key points of minimal genome research is to define the essentiality of genes for a cell. Comparative genomics [31, 32] , large-scale gene inactivation experiments [33] [34] [35] [36] [37] [38] , and network-based prediction [39] have been used to identify essential genes. Studies related to essential genes have been reviewed in refs [10, 40] . After experimental identification, results show that even in the genome of M. genitalium, the.....
Document: One of the key points of minimal genome research is to define the essentiality of genes for a cell. Comparative genomics [31, 32] , large-scale gene inactivation experiments [33] [34] [35] [36] [37] [38] , and network-based prediction [39] have been used to identify essential genes. Studies related to essential genes have been reviewed in refs [10, 40] . After experimental identification, results show that even in the genome of M. genitalium, there are about 100 protein coding genes regarded as non-essential [34] . Researches on E. coli or B. subtilis show that no more than ten percents of genome content are essential for both of them [36, 41] .
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