Author: Oh, Soo-Jin; Choi, Young-Ki; Shin, Ok Sarah
Title: Systems Biology-Based Platforms to Accelerate Research of Emerging Infectious Diseases Document date: 2018_3_1
ID: ta5y54lu_3
Snippet: Thus far, vaccines have been prepared by traditional methods, involving isolating infectious agents, attenuating or inactivating them, and exposing them to the immune system. 6 Although this traditional approach has proven very efficient ag-ainst pathogens with relatively low antigen variability, such as smallpox, polio, measles, mumps, and rubella, these approaches are not optimal to provide adequate protection against recently appearing EIDs, s.....
Document: Thus far, vaccines have been prepared by traditional methods, involving isolating infectious agents, attenuating or inactivating them, and exposing them to the immune system. 6 Although this traditional approach has proven very efficient ag-ainst pathogens with relatively low antigen variability, such as smallpox, polio, measles, mumps, and rubella, these approaches are not optimal to provide adequate protection against recently appearing EIDs, such as avian influenza virus infection, Ebola hemorrhagic fever, and dengue fever. 7, 8 Thus, novel systemic approaches are required to predict protective immune responses from high throughput sequencing and bioinformatics analysis and to identify potential antigenic targets to guide and accelerate vaccine development.
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