Author: Nicholls, John M
Title: The Battle Between Influenza and the Innate Immune Response in the Human Respiratory Tract Document date: 2013_3_29
ID: vyci1ho3_32
Snippet: TLR7, as mentioned before, is an intracellular receptor that recognizes ssRNA but only after the complex has been degraded in the endosome. Though it plays an important role in the innate defence mechanism, it is also involved in the antibody isotype switching and Katz and colleagues showed that TLR signaling was involved in the recruitment of myeloid-derived suppressor cells (MDSC) that play a role in the formation of the humoral immune response.....
Document: TLR7, as mentioned before, is an intracellular receptor that recognizes ssRNA but only after the complex has been degraded in the endosome. Though it plays an important role in the innate defence mechanism, it is also involved in the antibody isotype switching and Katz and colleagues showed that TLR signaling was involved in the recruitment of myeloid-derived suppressor cells (MDSC) that play a role in the formation of the humoral immune response, directing the acute adaptive response towards Th2 following influenza virus infection [58] .
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