Author: Hao, Xin-yan; Lv, Qi; Li, Feng-di; Xu, Yan-feng; Gao, Hong
Title: The characteristics of hDPP4 transgenic mice subjected to aerosol MERS coronavirus infection via an animal nose-only exposure device Document date: 2019_10_30
ID: vkjcheaz_48
Snippet: After MERS-CoV infection, IHC assays with a rabbit polyclonal anti-MERS-CoV NP antibody found that viral antigens predominantly appeared in tracheal endothelial cells at day 3 postinfection in the lungs of the aerosol-infected mice and in both tracheal endothelial cells and pneumocytes in the lungs of the aerosol-infected mice at 5-9 days; these changes were observed in the lungs of the instillation-infected mice at 3 and 5 days, respectively. In.....
Document: After MERS-CoV infection, IHC assays with a rabbit polyclonal anti-MERS-CoV NP antibody found that viral antigens predominantly appeared in tracheal endothelial cells at day 3 postinfection in the lungs of the aerosol-infected mice and in both tracheal endothelial cells and pneumocytes in the lungs of the aerosol-infected mice at 5-9 days; these changes were observed in the lungs of the instillation-infected mice at 3 and 5 days, respectively. In addition, the MERS-CoV antigen was discovered in the brain and kidneys in the aerosol group at 5-7 days and in the instillation group at 3 and 5 days. Based on these results, we concluded that the distribution of the MERS-CoV antigen in the lungs, brain and kidneys after infection was slower in the aerosol group than in the instillation group.
Search related documents:
Co phrase search for related documents- aerosol infect and MERS cov: 1, 2
- anti MERS CoV NP antibody and MERS cov: 1
- anti MERS CoV NP antibody and NP antibody: 1
- endothelial cell and kidney brain: 1, 2, 3, 4, 5
- endothelial cell and kidney brain lung: 1, 2
- endothelial cell and MERS cov: 1, 2, 3, 4, 5, 6, 7
- endothelial cell and MERS CoV antigen: 1
- endothelial cell and MERS cov infection: 1, 2
- endothelial cell and NP antibody: 1
- endothelial cell and pneumocyte endothelial cell: 1, 2
- IHC assay and NP antibody: 1, 2, 3
- instillation group and MERS cov: 1, 2, 3, 4, 5, 6
- instillation group and MERS cov infection: 1, 2
- kidney brain and MERS cov: 1, 2, 3, 4, 5
- kidney brain lung and MERS cov: 1, 2
- MERS cov and NP antibody: 1, 2, 3, 4, 5, 6
- MERS CoV antigen and NP antibody: 1
Co phrase search for related documents, hyperlinks ordered by date