Author: Jasenosky, Luke D.; Cadena, Cristhian; Mire, Chad E.; Borisevich, Viktoriya; Haridas, Viraga; Ranjbar, Shahin; Nambu, Aya; Bavari, Sina; Soloveva, Veronica; Sadukhan, Supriya; Cassell, Gail H.; Geisbert, Thomas W.; Hur, Sun; Goldfeld, Anne E.
Title: The FDA-Approved Oral Drug Nitazoxanide Amplifies Host Antiviral Responses and Inhibits Ebola Virus Document date: 2019_8_8
ID: yomg30hg_8
Snippet: We next tested the ability of NTZ pretreatment to activate IFN-b reporter gene activity in HEK293T cells cotransfected with a plasmid overexpressing MAVS, the adaptor protein through which RIG-I and MDA5 signal (Kawai et al., 2005; Meylan et al., 2005; Seth et al., 2005; Xu et al., 2005) . IFN-b LUC activity was strongly enhanced by NTZ in MAVS-overexpressing cells even in the absence of any other cellular stimulation, reaching a >4-fold increase.....
Document: We next tested the ability of NTZ pretreatment to activate IFN-b reporter gene activity in HEK293T cells cotransfected with a plasmid overexpressing MAVS, the adaptor protein through which RIG-I and MDA5 signal (Kawai et al., 2005; Meylan et al., 2005; Seth et al., 2005; Xu et al., 2005) . IFN-b LUC activity was strongly enhanced by NTZ in MAVS-overexpressing cells even in the absence of any other cellular stimulation, reaching a >4-fold increase at a concentration of 10 mM NTZ ( Figure 1C ).
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