Author: Bordes, Frédéric; Morand, Serge
Title: The impact of multiple infections on wild animal hosts: a review Document date: 2011_9_19
ID: rn4zitcs_18
Snippet: However, some parasites may prevent immune pathology in case of coinfections. Helminths have been shown to protect hosts against inflammatory diseases (42) . Helminth infections stimulate the dominance of T-helper 2 cells (Th2 response) and innate cell types such as mast cells and eosinophils (43) . These changes in the Th2 response create an anti-inflammatory environment favourable not only for parasite survival but also surprisingly for the hos.....
Document: However, some parasites may prevent immune pathology in case of coinfections. Helminths have been shown to protect hosts against inflammatory diseases (42) . Helminth infections stimulate the dominance of T-helper 2 cells (Th2 response) and innate cell types such as mast cells and eosinophils (43) . These changes in the Th2 response create an anti-inflammatory environment favourable not only for parasite survival but also surprisingly for the host. For example, infection with the trematode Fasciola hepatica suppresses immune responses to self-antigens and attenuates the clinical signs of experimental autoimmune encephalomyelitis in mice (the animal model for multiple sclerosis) (42) .
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