Author: Li, Li; Wang, Li; Xiao, Ruijing; Zhu, Guoguo; Li, Yan; Liu, Changxuan; Yang, Ru; Tang, Zhiqing; Li, Jie; Huang, Wei; Chen, Lang; Zheng, Xiaoling; He, Yuling; Tan, Jinquan
Title: The invasion of tobacco mosaic virus RNA induces endoplasmic reticulum stress-related autophagy in HeLa cells Document date: 2011_11_21
ID: r4c1sngt_6
Snippet: Recently, it has been discovered that autophagy is activated upon ERS as a defensive mechanism for survival [24] . In our study, we have demonstrated that TMV-RNA triggered autophagy in HeLa cells. Additionally, TMV-RNA was translated into CP, and the accumulation of CP in the ER induced ERS. For the first time, we observed suspected TMV virions in HeLa cells by TEM (transmission electron microscopy). Finally, we provide evidence that TMV-RNA-ind.....
Document: Recently, it has been discovered that autophagy is activated upon ERS as a defensive mechanism for survival [24] . In our study, we have demonstrated that TMV-RNA triggered autophagy in HeLa cells. Additionally, TMV-RNA was translated into CP, and the accumulation of CP in the ER induced ERS. For the first time, we observed suspected TMV virions in HeLa cells by TEM (transmission electron microscopy). Finally, we provide evidence that TMV-RNA-induced autophagy was caused by ERS in HeLa cells.
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