Author: van Griensven, Johan; De Weiggheleire, Anja; Delamou, Alexandre; Smith, Peter G.; Edwards, Tansy; Vandekerckhove, Philippe; Bah, Elhadj Ibrahima; Colebunders, Robert; Herve, Isola; Lazaygues, Catherine; Haba, Nyankoye; Lynen, Lutgarde
Title: The Use of Ebola Convalescent Plasma to Treat Ebola Virus Disease in Resource-Constrained Settings: A Perspective From the Field Document date: 2016_1_1
ID: riw5xs3j_35
Snippet: Current field experience supports the use of CP against EVD as acceptable, feasible, and safe. Efficacy data are pending. In consideration of the study design limitations described in this article, these trials may not yield definitive data on the extent to which such treatment reduces case fatality rates. However, it is expected that they will, at minimum, provide some indication of the utility of CP and the challenges in delivering such treatme.....
Document: Current field experience supports the use of CP against EVD as acceptable, feasible, and safe. Efficacy data are pending. In consideration of the study design limitations described in this article, these trials may not yield definitive data on the extent to which such treatment reduces case fatality rates. However, it is expected that they will, at minimum, provide some indication of the utility of CP and the challenges in delivering such treatment, in future trials. Additional research on CP, hyperimmune globulins, and monoclonal antibodies in animal and clinical studies is required to identify the optimal treatment regimen and better understand the mechanism of action.
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