Therapeutic Efficacy and Safety of Prolonged Macrolide, Corticosteroid, Doxycycline, and Levofloxacin against Macrolide-Unresponsive Mycoplasma pneumoniae Pneumonia in Children

Ha, Seok Gyun; Oh, Kyung Jin; Ko, Kwang-Pil; Sun, Yong Han; Ryoo, Eell; Tchah, Hann; Jeon, In Sang; Kim, Hyo Jeong; Ahn, Jung Min; Cho, Hye-Kyung

The incidence of macrolide resistance of MP has recently increased and has been related to life-threatening or refractory MP pneumonia in children. 16 Several studies on macrolide and alternative treatments for MRMP have been reported. However, data on their therapeutic efficacy and safety in children are still limited. We compared the therapeutic efficacy of PMC, CST, DXC, and LFX against macrolide-unresponsive MP pneumonia and collected data about their safety in children. Most of the patient achieved defervescence within 48 hours after the secondary treatment and any side effect was not observed in the CST, DXC, and LFX groups. However, TTD after initial macrolide treatment did not differ significantly between the PMC, CST, DXC, and LFX groups.