Author: Li, Dongbo; Ji, Hongfei; Niu, Xingjian; Yin, Lei; Wang, Yiran; Gu, Yucui; Wang, Jinlu; Zhou, Xiaoping; Zhang, Han; Zhang, Qingyuan
Title: Tumor-associated macrophages secrete CC-chemokine ligand 2 and induce tamoxifen resistance by activating PI3K/Akt/mTOR in breast cancer Document date: 2019_12_19
ID: yj9mb88g_5
Snippet: CM from tamoxifen-sensitive and -resistant breast cancer cells was tested for its ability to induce macrophage M2 polarization. We then examined the role of TAM in promoting tamoxifen resistance. We also identified a specific cytokine, CCL2, secreted by TAM to promote endocrine resistance and investigated its underlying mechanism of action. CCL2 immunohistochemistry was carried out on pathological sections from patients with invasive ER-positive .....
Document: CM from tamoxifen-sensitive and -resistant breast cancer cells was tested for its ability to induce macrophage M2 polarization. We then examined the role of TAM in promoting tamoxifen resistance. We also identified a specific cytokine, CCL2, secreted by TAM to promote endocrine resistance and investigated its underlying mechanism of action. CCL2 immunohistochemistry was carried out on pathological sections from patients with invasive ER-positive breast cancer to examine the correlation between CCL2 expression and disease prognosis. Our findings will further the understanding of how TAM promote tamoxifen resistance in breast cancer cells and may identify novel therapeutic targets for patients with endocrine-resistant breast cancer.
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