Author: Evans, Claire F.; Horwitz, Marc S.; Hobbs, Monte V.; Oldstone, Michael B.A.
Title: Viral Infection of Transgenic Mice Expressing a Viral Protein in Oligodendrocytes Leads to Chronic Central Nervous System Autoimmune Disease Document date: 1996_12_1
ID: t82a9y5s_1
Snippet: T he concept of molecular mimicry has been proposed for the etiology of autoimmune diseases (1) (2) (3) (4) (5) . In molecular mimicry, a pathogen such as a virus shares peptide sequences or conformations with a host protein. The immune response to the viral infection results in a cross-reactive autoimmune attack against a target tissue expressing the mimicked protein. To date, molecular mimicry has been suggested to play a role in the pathogenes.....
Document: T he concept of molecular mimicry has been proposed for the etiology of autoimmune diseases (1) (2) (3) (4) (5) . In molecular mimicry, a pathogen such as a virus shares peptide sequences or conformations with a host protein. The immune response to the viral infection results in a cross-reactive autoimmune attack against a target tissue expressing the mimicked protein. To date, molecular mimicry has been suggested to play a role in the pathogenesis of several human diseases, including insulin-dependent diabetes mellitus (6) , ankylosing spondylitis (7), Guillain-Barre syndrome (8) , primary biliary cirrhosis (9) , and multiple sclerosis (MS) 1 (10) (11) (12) , but has yet to be conclusively shown to be the initiating factor of these autoimmune diseases.
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