Author: Méndez-Sánchez, Nahum; Valencia-Rodríguez, Alejandro; Qi, Xingshun; Yoshida, Eric M.; Romero-Gómez, Manuel; George, Jacob; Eslam, Mohammed; Abenavoli, Ludovico; Xie, Weifen; Teschke, Rolf; Carrion, Andres F.; Keaveny, Andrew P.
Title: What Has the COVID-19 Pandemic Taught Us so Far? Addressing the Problem from a Hepatologist’s Perspective Document date: 2020_4_11
ID: tiixwaqi_9
Snippet: Systemic inflammation and the subsequent multiple organ failure triggered by severe NCP would undoubtedly act synergistically in the development of liver injury. COVID-19 has been reported to upregulate the expression of proinflammatory cytokines, like IL-1b, IL-6, and tumor necrosis factor-alpha. 2 These cytokines are upregulated in a wide number of liver disorders, including viral hepatitis, metabolic associated fatty liver disease, and alcohol.....
Document: Systemic inflammation and the subsequent multiple organ failure triggered by severe NCP would undoubtedly act synergistically in the development of liver injury. COVID-19 has been reported to upregulate the expression of proinflammatory cytokines, like IL-1b, IL-6, and tumor necrosis factor-alpha. 2 These cytokines are upregulated in a wide number of liver disorders, including viral hepatitis, metabolic associated fatty liver disease, and alcoholic liver disease. The use of antipyretics, such as paracetamol, and certain antivirals, like oseltamivir, lopinavir and ritonavir, for the management of COVID-19 has been widely reported to be associated with the development of liver injury. 19 What precautions, then, should patients with chronic liver disease follow during this pandemic? Due to the exponential increase in cases of infection worldwide, it is very likely that gastroenterologists and hepatologists will encounter patients with chronic liver disease and concomitant COVID-19 infection.
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