Author: Dawson, Patrick; Malik, Mamunur Rahman; Parvez, Faruque; Morse, Stephen S.
Title: What Have We Learned About Middle East Respiratory Syndrome Coronavirus Emergence in Humans? A Systematic Literature Review Document date: 2019_3_1
ID: yb54i1ne_101
Snippet: Genome sequencing has proved useful in several respects. Genome sequencing was used to help determine viral circulation and ancestry (Cotten et al. 2014) , and to differentiate apparently similar and serologically cross-reacting coronaviruses in camels, addressing the (still unresolved) question of why MERS seems regionally limited, while many camels are imported from other places (Chu et al. , 2018 . It has also been used to reconstruct the tran.....
Document: Genome sequencing has proved useful in several respects. Genome sequencing was used to help determine viral circulation and ancestry (Cotten et al. 2014) , and to differentiate apparently similar and serologically cross-reacting coronaviruses in camels, addressing the (still unresolved) question of why MERS seems regionally limited, while many camels are imported from other places (Chu et al. , 2018 . It has also been used to reconstruct the transmission events and help to establish chains of infection (Assiri et al. 2013b ), but it must be noted that there is a pressing need for more rigorous conventional epidemiology as well to validate the methodologies. These approaches might well serve a complementary function in advancing our understanding.
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