Author: Hsieh, Wen-Yeh; Kuan, Tang-Ching; Cheng, Kun-Shan; Liao, Yan-Chiou; Chen, Mu-Yuan; Lin, Pei-Heng; Hsu, Yuan-Chang; Huang, Chen-Yi; Hsu, Wei-Hua; Yu, Sheng-Yao; Lin, Chih-Sheng
Title: ACE/ACE2 Ratio and MMP-9 Activity as Potential Biomarkers in Tuberculous Pleural Effusions Document date: 2012_10_17
ID: zlzig0nn_37
Snippet: Our data suggest that the interplay between ACE and ACE2, an essential function in RAS, and the change in gelatinase activity may be involved in the development of pleural effusions. Our findings suggest that increased ACE and MMP-9 activities and decreased ACE2 activity in pleural fluid are features of pleural space infection in patients with pleural tuberculosis. Such measurements may be helpful for diagnosing tuberculous pleurisy. However, the.....
Document: Our data suggest that the interplay between ACE and ACE2, an essential function in RAS, and the change in gelatinase activity may be involved in the development of pleural effusions. Our findings suggest that increased ACE and MMP-9 activities and decreased ACE2 activity in pleural fluid are features of pleural space infection in patients with pleural tuberculosis. Such measurements may be helpful for diagnosing tuberculous pleurisy. However, the findings of the present study require further validation in a large prospective study examining the treatment and outcome of unselected patients with tuberculosis before the above indicators can become part of a clinically meaningful practice.
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