Author: WU, Hong-Xia; WANG, Hua-Lei; GUO, Xiao-Feng; YANG, Yu-Jiao; MA, Jin-Zhu; WANG, Tie-Cheng; GAO, Yu-Wei; ZHAO, Yong-Kun; YANG, Song-Tao; XIA, Xian-Zhu
Title: Adeno-Associated Viruses Serotype 2-Mediated RNA Interference Efficiently Inhibits Rabies Virus Replication In Vitro and In Vivo Document date: 2013_6_14
ID: sj9k4c3i_1
Snippet: Rabies is a disease of the central nervous system that constantly produces victims in human beings as well as in animals. Rabies cases are reported worldwide, but are most prevalent in undeveloped countries, specifically in rural areas of Africa and Asia. No definitive and effective treatment has been established to cure the disease once the clinical stage has been reached, and only a small portion of clinical cases responds to intensive therapeu.....
Document: Rabies is a disease of the central nervous system that constantly produces victims in human beings as well as in animals. Rabies cases are reported worldwide, but are most prevalent in undeveloped countries, specifically in rural areas of Africa and Asia. No definitive and effective treatment has been established to cure the disease once the clinical stage has been reached, and only a small portion of clinical cases responds to intensive therapeutic management and survives [19] . Once the clinical symptoms of rabies appear, conventional post-exposure treatment is unsuccessful, because of its inability to cross the blood-brain barrier [9] . Thus, the current strategy to control rabies is pre-exposure prophylaxis by vaccine injection, but research efforts are focused on developing an effective, safe prophylactic and/or therapeutic tool against RAbV infection.
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